Suriyavathana
Periyar University, India
Title: Biogenic nanosynthesis of anisomeles malabarica leaves(AgNps) and cytotoxic effect on HepG2 cell lines
Biography
Biography: Suriyavathana
Abstract
Nanoscience and nanotechnology have been an interesting field of research and gained much importance from last two decades. Nanotechnology is fundamentally changing the way in which materials are synthesized and devices are fabricated. Incorporation of nanoscale building blocks into functional assemblies and further into multifunctional devices can be achieved
through a “bottom-up approach”. Research on the synthesis of nanosized material is of great interest because of their unique properties like optoelectronic, magnetic, and mechanical, which differs from bulk. Nanostructured materials are being viewed as the future material and for
various diverse applications in areas such as biomedical science, optics, mechanics, magneticscatalysts, biosensors and energy science.
Biological methods can be used to synthesize silver nanoparticles without the use of any harsh, toxic and expensive chemical substances. Green synthesis approaches of producing NPs are an alternative source of conventional method and possess excellent antimicrobial activity.Nonalcoholic fatty liver disease is a common clinic pathological condition characterized by significant lipid deposition in the hepatocytes of the liver parenchyma. The pathological picture
bears a striking resemblance to that of alcohol-induced liver injury, but it occurs in individuals who deny a significant history of alcohol ingestion. The effect of complex mixtures on several cellular responses, in an invitro liver model using human hepato carcinoma (HepG2) cells, was studied.
The synthesis nanoparticles were characterized by Uv-Visisble sepectroscopy, FTIR, SEM and EDX, TEM,XRD. AgNps of A.malabarica on HepG2 cell line showed dose dependent activity performed by laura talarico, 2004 method. The AgNP’s exhibited good cytotoxic effect . Activation of the caspase-3 pathway is a hallmark of apoptosis and can be used in cellular assays to quantifyactivators and inhibitors of the “death cascade.” The nano based phyto medicine will certainly provide and serve the line of safety and also willbe used as eco- friendly than allopathicchemically synthesized drugs in future.